Is N2 A Triple Bond

Breaking the N₂ triple bail: insights into the nitrogenase mechanism

Author affiliations

* Respective authors

^a Section of Chemistry and Biochemistry, Utah State Academy, Logan, UT, USA
Electronic mail: seefeldt@cc.usu.edu
Tel: 435-797-3964

^b Department of Biochemistry, Virginia Tech, Blacksburg, VA, USA
E-mail: deandr@vt.edu
Tel: 540-231-5895

^c Department of Chemistry Didactics, Kyungpook National University, Daegu, Korea
E-mail: leehi@knu.ac.kr

^d Department of Chemical science, Northwestern Academy, Evanston, IL, USA
Eastward-mail: bmh@northwestern.edu
Tel: 847-491-3104

Abstruse

Nitrogenase is the metalloenzyme that performs biological nitrogen fixation by catalyzing the reduction of N _two to ammonia. Agreement how the nitrogenase active site metal cofactor (FeMo-cofactor) catalyzes the cleavage of the N ₂ triple bond has been the focus of intense report for more than 50 years. Goals have included the determination of where and how substrates collaborate with the FeMo-cofactor, and the nature of reaction intermediates forth the reduction pathway. Progress has included the trapping of intermediates formed during turnover of non-physiological substrates (e.g., alkynes, CS ₂ ) providing insights into how these molecules interact with the nitrogenase FeMo-cofactor active site. More recently, substrate-derived species accept been trapped at loftier concentrations during the reduction of N _two , a diazene, and hydrazine, providing the offset insights into binding modes and possible mechanisms for Due north ₂ reduction. A comparison of the current state of knowledge of the trapped species arising from not-physiological substrates and nitrogenous substrates is beginning to reveal some of the intricacies of how nitrogenase breaks the North ₂ triple bond.

Graphical abstract: Breaking the N2 triple bond: insights into the nitrogenase mechanism

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Article information

DOI: https://doi.org/x.1039/B517633F
Article blazon: Perspective
Submitted: xiii Dec 2005
Accepted: 29 Mar 2006
First published: xi Apr 2006

Download Citation

Dalton Trans. , 2006, 2277-2284

Permissions

Breaking the N _ii triple bond: insights into the nitrogenase mechanism

B. M. Barney, H. Lee, P. C. Dos Santos, B. One thousand. Hoffman, D. R. Dean and L. C. Seefeldt, Dalton Trans., 2006, 2277 DOI: 10.1039/B517633F

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